Vitamin D toxicity is also called hypervitaminosis D. The calcium can bind to other tissues, including your kidneys, and damage them. High calcium levels can cause various symptoms. One of the main signaling processes has to do with increasing the absorption of calcium from your digestive system and bones ( 3).Īs a result, the main sign of vitamin D toxicity is hypercalcemia, or elevated calcium levels in your blood ( 4, 5).
This may lead to elevated levels of “free” vitamin D in your body, which may travel inside cells and overwhelm the signaling processes affected by vitamin D. However, when vitamin D intake is extremely high, your levels can become so high that there isn’t any room left on the receptors or carrier proteins. Very little “free” vitamin D is available ( 1, 2). Usually, most of your body’s vitamin D is in storage, bound to either vitamin D receptors or carrier proteins. It travels inside cells, telling them to turn genes on or off. However, we know that the active form of vitamin D functions similarly to a steroid hormone. The exact mechanism behind vitamin D toxicity is complicated and isn’t fully understood at this point. In contrast to water-soluble vitamins, your body has no easy way to get rid of fat-soluble vitamins.įor this reason, excessive amounts may build up in your body. Healthcare professionals may also call it hypervitaminosis D. Vitamin D toxicity occurs when vitamin D levels in your body are so high that they cause harm.
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